That particular file can be found at:
https://github.com/atutor/ATutor/blob/atutor_2_1_1/themes/default/admin/courses/edit_course.tmpl.php
You can try removing the following line:
[php]
require_once(AT_INCLUDE_PATH.'../mods/_core/courses/html/course_icon.inc.php');
[/php]
If that brings back the Save button, it might mean the image processing libraries are not included with your PHP (--with-gd, --with-jpeg-dir). See the requirements section for a list of libraries that should be installed:
http://atutor.ca/atutor/docs/requirements.php
Or, by any chance when you installed ATutor, did you upload the bundle and unpack it on the server, or unpack it on a local computer and upload file-by-file. The later can cause these seemingly random problems.